Health Tests · Labcorp OnDemand
NASHnext Liver Risk Test, $279
$279 · no doctor visit needed
- Order online, walk into 2,000+ locations — no appointment
- Physician order included — no doctor visit required
- Results in your portal in days
Same certified lab your doctor uses. HSA/FSA accepted.
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Order online for $279, walk into any of 2,000+ locations — no doctor's visit needed. Four blood markers, combined by an algorithm into one risk score for metabolic fatty liver disease — the kind standard liver enzymes can miss — with results in 7–17 days.
The short version
$279, one walk-in visit, results in 7–17 days
The NASHnext Advanced Liver Risk Test ($279) measures four blood markers and combines them into a single score that estimates the likelihood of metabolic-related fatty liver conditions such as MASH (formerly called NASH) and moderate to advanced fibrosis. It exists for one gap in ordinary testing: standard liver enzymes can read normal even when liver changes are present. The score is a risk estimate, not a diagnosis — an abnormal result is a reason to talk to a clinician, not a verdict.
Shopping links on this page go directly to Labcorp OnDemand. We don't earn a commission on orders.
Price
| Test | Price | |
|---|---|---|
| NASHnext® Advanced Liver Risk Test | $279 | Order now → |
Prices checked Nov 10, 2026. HSA/FSA eligible. Self-pay; insurance not billed.
What the four markers measure — and why one score
Four blood markers, each a different piece of the liver picture, are combined by an algorithm (called NIS4) into a single risk score. miR-34a-5p reflects changes in liver cells that occur with liver stress, inflammation, and scarring, and is linked to how liver cells manage fat and respond to injury. YKL-40 is linked to immune-cell activity and may rise with ongoing liver inflammation or scarring. Alpha-2-macroglobulin is a protein that can increase as the body responds to liver scarring over time. HbA1c shows average blood sugar over the past few months; higher levels are associated with metabolic stress, which can affect liver health and inflammation. No single marker carries the result — the score reads the pattern across all four.
Why ALT and AST can miss it
Standard liver enzyme tests — ALT and AST — measure a limited set of markers, and they can sit inside the normal range even when liver changes are already present. That is the gap this test is built for: metabolic fatty liver disease is often silent, with no symptoms while fat builds up and scarring begins, and a normal enzyme panel can give false reassurance. The four-marker score looks for the pattern associated with fat buildup, inflammation, and fibrosis rather than asking two enzymes to tell the whole story. It does not replace imaging or a clinician workup — it flags whether that workup is worth having.
What the score can and cannot tell you
The result places you in a risk category for metabolic-related liver conditions — an estimate of likelihood, not a diagnosis. The test itself states plainly that results are not diagnostic and cannot tell you whether you have liver disease; they are meant to support follow-up discussions with a healthcare provider as part of a full health evaluation. A lower-risk score does not rule out liver disease, and a higher-risk score does not confirm it — either way, the next step is a clinician conversation, possibly with imaging or further testing.
This test is not intended for people whose liver concerns are likely caused by other conditions — viral hepatitis, alcohol-related liver disease, medication-related liver injury, genetic or autoimmune liver diseases, or certain bile duct disorders. If any of those apply, this score answers the wrong question and the testing should run through your clinician.
Who should consider it — and who should skip it
This test fits adults at higher risk for metabolic-related fatty liver conditions — people with type 2 diabetes or abnormal metabolic health markers — who want a noninvasive read on their liver risk before symptoms appear. The at-risk group is large: metabolic fatty liver disease is common and usually silent, so the people who benefit most are the ones with metabolic risk factors and no liver symptoms yet. It is the wrong purchase if your liver concern likely has another cause (see above), or if you already have diagnosed liver disease — then your testing should run through your clinician, who can order the right workup and read it against your history. Medicare covers this test for patients who meet its coverage criteria; otherwise the self-pay price is shown at the top of this page.
How walk-in NASHnext testing works
You order the test online, then visit a patient service center for a standard venous blood draw — no doctor’s order, no appointment, and no insurance needed. The one prep rule that matters: fast for 12 hours before the sample collection (no food or drink except water). Results typically post to a secure portal 7 to 17 days after your sample arrives at the lab — longer than a standard blood test, because the marker analysis and scoring take time. HSA/FSA accepted. The test must be taken by the purchaser, and it is available to adults 18 to 100.
Common questions
Do I need to fast before a NASHnext test?
Yes. Fast for 12 hours before the blood draw — no food or drink except water. The fasting requirement is specific to this test, so do not assume the prep from another test you have taken.
Is this a home test kit?
No. This is an in-person visit: a blood draw at a patient service center. You order online, then walk in for the draw — no appointment and no doctor visit required.
How long do results take?
Typically 7 to 17 days from when your sample arrives at the lab — longer than a standard blood test, because the four markers are analyzed together and combined into the risk score. Results post to a secure online portal.
Can this test diagnose fatty liver disease or MASH?
No. The result is a risk estimate — a score that places you in a risk category — not a diagnosis. It cannot tell you whether you have liver disease. An abnormal result is a reason to talk to a clinician about follow-up, possibly imaging or further testing.
My liver enzymes are normal — do I need this test?
Possibly, if you have metabolic risk factors. Standard liver enzymes can read normal even when liver changes are present, which is exactly the gap this test addresses. But with normal enzymes and no metabolic risk factors — no diabetes, no abnormal metabolic markers — it is a low-yield purchase. Ask your clinician whether your risk profile warrants it.
Is NASHnext covered by insurance or Medicare?
Medicare covers this test for patients who meet its coverage criteria. For everyone else it is a self-pay purchase — the price is shown at the top of this page — and HSA/FSA funds are accepted.
Ready to order?
Get your liver risk score this month
Order the NASHnext Advanced Liver Risk Test for $279 and walk in this week after a 12-hour fast — no doctor visit required.